Chris Redfield enlists the help of Leon S. Kennedy and Rebecca Chambers to stop a death merchant, with a vengeance, from spreading a deadly virus in New York.

United States Special Agent Leon S. Kennedy sneaks into a small Eastern European country to verify rumors that Bio Organic Weapons (B.O.W.s) are being used in war. Right after his infiltration, the U.S. government orders him to leave immediately. Determined to uncover the truth, Leon ignores the order and enters the battlefield to end the chain of tragedies caused by the B.O.W.s. Written by KalantarAhUra

In San Francisco, Jill Valentine is dealing with a zombie outbreak and a new T-Virus, Leon Kennedy is on the trail of a kidnapped DARPA scientist, and Claire Redfield is investigating a monstrous fish that is killing whales in the bay. Joined by Chris Redfield and Rebecca Chambers, they discover the trail of clues from their separate cases all converge on the same location, Alcatraz Island, where a new evil has taken residence and awaits their arrival.